Nov 2006 STUDIES - BINARY MIXTURE OF DIOXINS: PCB

3,3N,4,4N,5-PENTACHLOROBIPHENYL 
(PCB 126)
(CAS NO. 57465-28-8)



AND

2,3N,4,4N,5-PENTACHLOROBIPHENYL 
(PCB 118)
(CAS NO. 31508-00-6)


Results 

Female rats administered the mixtures of PCB 126 and PCB 118 developed a variety of diseases in several organs, including cancers of the liver, lung, and mouth.  

A variety of other toxic lesions observed in exposed animals included 

hypertrophy
hyperplasia
hepatopathy
fibrosis, and necrosis of the liver
hyperplasia of the oral mucosa
metaplasia of the lung
atrophy of the thymus
hypertrophy of the thyroid gland
atrophy of the adrenal cortex
vacuolization and atrophy of the pancreas
kidney nephropathy
hyperplasia of the nose
hyperplasia of the forestomach
hemorrhage of lymph nodes and brain
atrophy of the spleen. 

Conclusions 
We conclude that the mixtures of PCB 126 and PCB 118 caused cancer and other toxic effects at several sites in female rats.

Study Results 
niehs.nih.gov: Paper published